• Treats many kinds of persistent pain
  • Especially effective for nerve or neuropathic pain
  • Affects the nerve cells in the body
  • Genuine medication
  • All drugs sourced in the UK




Amitriptyline belongs to a class of medications known as tricyclic antidepressants but is rarely used as a antidepressant. It works on the central nervous system to increase certain chemicals in the brain, which improves pain.

Please note: this page is only to be used as a reference of our price for this medication. If you are approved for Chronic Conditions medication, you will be offered treatment for you and the prescriber to jointly consider. However, the final decision will always be the prescriber's.  

What is Amitriptyline? 

  Amitriptyline is a medication that is prescribed to people who suffer from mood or mental problems, such as depression. Symptoms of these problems can lead to people feeling anxious and tense. Moreover, they may have difficulty sleeping and have low energy levels. To address this issue, doctors recommend the usage of Amitriptyline, which belongs to a group of drugs and medications that are named tricyclic antidepressants. Even though it’s been widely known to treat depression, Amitriptyline can also be used to treat pain, such as neuralgia, back pain and migraine attacks, as long as the dosage is low enough.    Amitriptyline is a prescription-only medication that can come in many forms such as a liquid or as a tablet. The effects of this drug can make you feel sleepy or drowsy so it’s important to take them right before you go to sleep. Patients taking this medication can feel a difference at least a week later. When it comes to working as a painkiller, it may take at least 6 weeks for the full effects to sink in. It’s important to keep drinking it, even if you may not feel the effects immediately. Side-effects can occur if you suddenly stop taking the drug.    Depending on your condition, you can take this antidepressant for months or even years. No lasting or harmful effects have been recorded by the people using them for long periods of time. You can expect changes in weight as this drug can affect your appetite. For example, some patients have reported feeling more hungry after taking it.   

How does Amitriptyline work?

  Since it belongs to tricyclic antidepressants, Amitriptyline increases the serotonin levels in your brain, which can drastically affect your overall mood. Additionally, it helps relieve pain by changing the way certain nerves in your body receive pain signals. Overall, you can expect this medication to affect the balance in the chemicals in your brain, which will lead to better moods and relief in pain.   

Who can and can’t take Amitriptyline?

  Amitriptyline isn’t suitable for everybody, despite its guaranteed effects when it comes to pain relief. Most adults can take this antidepressant. Children aged 2 years and above can also take it if they have some kind of nerve pain. However, here is a list of people who can’t and shouldn’t take Amitriptyline:   
  • People who have had allergic reactions to Amitriptyline or certain medicines in the past.
  • People who have had heart problems or conditions. 
  • People who suffer from a rare illness called porphyria, which refers to a classification of disorders that are caused by a buildup of natural chemicals. 
  • People who have had kidney or liver problems. 
  • People who have had epilepsy. 
  • People who have taken other medicines for depression that can interfere with Amitriptyline. 
  • People who are trying to get pregnant, are already pregnant or are breastfeeding. 
  • People who have an eye condition called glaucoma. 
  • People who are suicidal or have thought of ending their life. 
  • People who have diabetes. 

What are the benefits of using Amitriptyline? 

  For people living with anxiety and depression, it can be difficult for them to focus on their daily activities and stay productive in their life. Moreover, they might have difficulty searching for meaning in their life, which can be dangerous if they aren’t given the right treatment. With the help of Amitriptyline, people can experience elevated moods and pain relief. This can help them sleep better, relieve any tension and increase energy levels. Overall, it’s a medication that will improve their mood.   

What are the side-effects of using Amitriptyline? 

  Like all drugs and medicines, side-effects are guaranteed. You might experience most of these during the entire time you’re taking Amitriptyline. But there’s nothing to worry about as most of these side-effects are mild and will eventually wear off, especially if you’re only taking Amitriptyline for pain relief. But if some of these symptoms continue to persist, then you should immediately inform your doctor.    Here are the most common side-effects people taking Amitriptyline experience:   
  • Dizziness
  • Dry mouth
  • Constipation
  • Drowsiness
  • Difficulty in peeing
  • Headaches 
  Some rarer side-effects can also happen, which is more serious. Don’t wait for these symptoms to come back. Immediately call your doctor if you feel the following:   
  • Irregular heartbeats
  • Yellowish skin which can point to liver problems
  • Headaches 
  • Muscle cramps
  • Seizures 
  • Swelling of the eye or a change in eyesight 
  • Severe constipation 
  • Stroke 
  People can also be allergic to Amitriptyline, which is why it’s important to look out for the symptoms. If you experience the following, then immediately call 999 or go to the hospital:   
  • Wheezing 
  • Tightness in the throat or chest
  • Skin rash
  • Difficulty in breathing
  • Swelling of the mouth, face, throat, tongue or lips 

How do you take Amitriptyline? 

  When your doctor prescribes you Amitriptyline, they will also give you a list of instructions that you need to follow carefully. It helps to check the Patient Information Leaflet that can be found in the medication package. You can also ask a doctor or a pharmacist if you still have more questions.    Patients are usually instructed to take Amitriptyline one to four times a day every day. If you’ve been instructed to only take this once, then you should take it with a glass of water right before bed time as it can cause drowsiness. It’s important to take note that Amitriptyline won’t give you instantaneous results. It may take a week or 4 weeks for you to experience the full benefits.  

What is the right dosage of Amitriptyline? 

  For adults aged 18 to 64 years old, Amitriptyline can come in different strengths: 
  • 75 mg is the starting dosage 
  • 150mg is the maximum dosage 
  • For the alternative dosage routine, start with 50 to 100mg right before going to sleep, increase it by 25 or 50 mg to have the maximum dosage of 150 mg per day. 

Are there other alternatives to Amitriptyline? 

  Depending on your condition, you can opt for other medications in treating pain, especially if you’re one of the people who can’t take Amitriptyline due to a number of health reasons.    Below, you’ll find other alternatives to Amitriptyline:   
  • Paracetamol for pain relief
  • Pregabalin typically used for epilepsy
  • Propranolol for high blood pressure
  • Physiotherapy

Where can you purchase Amitriptyline?

  Amitriptyline is available in most local pharmacies, provided that you have a prescription signed by a doctor. But during the pandemic, it may be difficult to leave your house. So, you can always opt for buying from an online store but take note that you also need to present a prescription. If you’re worried about not having a prescription, don’t worry. Some virtual pharmacies offer online consultation with a doctor. Once you’ve been given your prescription, find a valid and reliable virtual pharmacy to buy from.
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